Tri-Specific Antibodies Treating HIV Infection

The medicine industry is booming, thanks to new technologies like bendable batteries and injectable bandages. While these new discoveries can treat cancer and repair organs, some researchers are working on improving older remedies. The US National Institutes of Health and Sanofi have combined antibodies into tri-specific antibodies targeting HIV infection.

“They are more potent and have greater breadth than any single naturally occurring antibody that’s been discovered.” [said Dr. Gary Nabel of Sanofi.]

“We’re getting 99% coverage, and getting coverage at very low concentrations of the antibody,”

HIV strains mutate faster than immune systems can adapt, making resistance almost futile. Animal trials saw a 100% success rate in monkeys, while human trials will begin next year.

“Combinations of antibodies that each bind to a distinct site on HIV may best overcome the defences of the virus in the effort to achieve effective antibody-based treatment and prevention.”

Further testing may prove the usefulness of tri-specific antibodies in other fields. The battle against HIV is far from over, but it’s safe to say we’re getting there, one antibody at a time.

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Why We Need to Celebrate the Smallpox Vaccine

In light of brilliant breakthroughs like gene alteration for genetic disorders, nanomachines to cure cancer cells, minimally invasive treatment procedures for epilepsy — no, the smallpox vaccine doesn’t seem like a big deal. It obviously isn’t a new medical discovery. In fact, last May 8 commemorates the fact that the world has been free of the illness for 38 years. But the reason we need to celebrate it is precisely because of the many successes that followed the 1980s smallpox eradication. And the need to counter the threats to these successes.

William Foege, former director of the Centers for Disease Control and Prevention, has written a book in 2011 called House on Fire where he explains just how he made it possible. He and other health workers wiped out smallpox — “by dreaming, being savvy in politics and unafraid to break the rules, and devising the brilliant ring vaccination strategy.”

Foege and his colleagues found that instead of using the vaccine on entire populations, it was more effective to distribute it among the demographic most at risk, which were the contacts of the infected. After being proven true in the smallpox case, this strategy on immunization was replicated on the prevention of other diseases or viruses such as measles, polio, malaria, HIV/AIDS, Ebola, and others. Some have been nearly wiped out as well, while the incidence rates of some have significantly dropped.

However, a few decades later, people now face a dilemma. What about the now-debunked finding that vaccine causes autism? The anti-vaccine movement discredits the milestones of smallpox eradication and immunization. Does the use of vaccine actually pose more risk than benefit to humans? Well, it might be time to look back at history for answers regarding the progress of human health. William Foege, the man who developed the global strategy for vaccination, is still fighting for truth.

“I think vaccines are really the foundation of public health . . . By the early 1980s, [many of] our vaccine diseases had gone down to close to zero . . . So things were going quite well until Andrew Wakefield did his Lancet article [suggesting there’s a link between the measles-mumps-rubella vaccine and autism] . . . He specifically said the MMR vaccine was the problem. He was disbarred in England because of the falsifications of his [data].”

Turns out, the research linking vaccines to autism is completely bogus that Wakefield even lost his medical license. But that hasn’t stopped parents all over the world from being paranoid. Foege understands that parents are only “trying to do the right thing,” but in doing so, they forget the risk of disease and focus on a completely false risk of the vaccine. This seems to make the anti-vaccine movement more of a health education issue, as people are just clearly misinformed.

38 years after smallpox eradication and other successes, vaccination has become a social problem more than a scientific one. In some countries, the public health debate even results in violence. But globally, more often than not, it results in the slower prevention and elimination of certain diseases. But Foege is still hopeful.

“I think we’re at the beginning of an eradication era — because of vaccines — and as we learn more and more about logistics, cold chains, how to develop vaccines that don’t require refrigeration, don’t require using needles and syringes, I think the future is very bright for disease eradication . . . You have to believe a disease can be eradicated . . . you have to put up with all the frustrations . . . you stick with your vision of what the last mile is.”

True enough, a disease can be eradicated. Smallpox is a testament to that. So celebrate the fact that you were born after it’s gone. Celebrate the fact that it led to much slimmer chances of measles in your lifetime. Now more than ever, we need to celebrate this feat, so that decades of medical history — thus, strong leads to medical progress — will not go down the laboratory drain.

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