Modified Chickens Are Laying Cancer-Fighting Eggs

With alternative treatments for cancer on the rise, we’re also seeing an increase in unusual remedies. If anything from avocado husks to flexible batteries are on the market, using livestock should be no surprise. At least not to engineers in Japan. Researchers are genetically modifying chickens to lay eggs filled with cancer-preventing drugs.

The eggs were developed using genome-editing technology to produce a protein called interferon, which is used to treat hepatitis, multiple sclerosis and malignant skin cancer.

Injecting it into cancer patients three times per week can prevent cancer cells from multiplying, while also boosting T cells to fight tumors.

Conventionally, interferon costs anywhere between $250 to $900. Interferon from chicken eggs, on the other hand, won’t have patients clucking up more than half the price. What remains to be more dangerous than cancer itself is the price tag that comes with therapy.

“Cancer drugs are not a luxury item, like an expensive car, that people can choose to buy or not to buy…. When prices come down, mortality rates will surely follow.” [said Brian Bolwell of the Cleveland Clinic.]

Perhaps, one day we’ll all agree that curing cancer isn’t about the money. Kudos, Mr. Bolwell. Kudos.

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Pediatric Cancer Drug Displays 93% Success Rate

Breakthroughs in cancer research such as gene-altering treatments and the discovery of nanomachines have made waves in the past few years, persistently leading humanity through not-so-tiny victory after not-so-tiny victory in a battle between human and disease that has spanned decades. Just this month, a drug specifically targeting a fused gene found in several cancer types resulted in a 93% response rate among children.

“In some cancers, a part of the TRK [tropomyosin receptor kinase] gene has become attached to another gene, which is called a fusion. When this occurs, it leads to the TRK gene being turned on when it’s not supposed to be and that causes the cells to grow uncontrollably. What’s unique about the drug is it is very selective; it only blocks TRK receptors,” said lead author Dr. Ted Laetsch, Assistant Professor of Pediatrics.

Most drugs that are already known and used to cure cancer usually target a particular location or organ in the body. According to the researchers at UT Southwestern’s Simmons Cancer Center, Larotrectinib is the first cancer drug designated for people with TRK fusions, or the fusion of two genes in the cancer cell, regardless of whether their cancer is in the lung, colon, or other areas.

“…none of the patients with TRK fusions had to quit the study because of a drug-induced side effect. Equally important, the response was long-lasting for most patients.”

The TRK fusions tend to occur mostly in certain types of pediatric cancer. This implies that, despite also being 75% effective in adult cancers, Larotrectinib is a bigger breakthrough in pediatric cancer research. This is a hopeful and life-giving discovery for children, or the people most capable of giving us hope in our own lives.

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