Tri-Specific Antibodies Treating HIV Infection

The medicine industry is booming, thanks to new technologies like bendable batteries and injectable bandages. While these new discoveries can treat cancer and repair organs, some researchers are working on improving older remedies. The US National Institutes of Health and Sanofi have combined antibodies into tri-specific antibodies targeting HIV infection.

“They are more potent and have greater breadth than any single naturally occurring antibody that’s been discovered.” [said Dr. Gary Nabel of Sanofi.]

“We’re getting 99% coverage, and getting coverage at very low concentrations of the antibody,”

HIV strains mutate faster than immune systems can adapt, making resistance almost futile. Animal trials saw a 100% success rate in monkeys, while human trials will begin next year.

“Combinations of antibodies that each bind to a distinct site on HIV may best overcome the defences of the virus in the effort to achieve effective antibody-based treatment and prevention.”

Further testing may prove the usefulness of tri-specific antibodies in other fields. The battle against HIV is far from over, but it’s safe to say we’re getting there, one antibody at a time.

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Nerve Therapy Revives Consciousness Of Patients

A mere month ago, locked-in patients were given the opportunity to communicate via a computer interface. Now, researchers are using nerve therapy to revive the consciousness of patients in a persistent vegetative state.

The vagus nerve, which the treatment targeted, connects the brain to almost all the vital organs in the body, running from the brain stem down both sides of the neck, across the chest and into the abdomen. In the brain, it is linked directly to two regions known to play roles in alertness and consciousness.

The study, led by French scientists, brought a 35-year-old man out of PVS after being unresponsive for nearly 15 years. He can now track objects with his eyes and even turn his head when asked. Head of study Angela Sirigu believes the research can provide hope for families of locked-in patients.

“Personally I think it’s better to be aware, even if it’s a bad state, to be conscious of what’s happening. Then you can have a decision if you want to go on or if you want [euthanasia].”

At the very least, those in a locked-in state can be in control, which eliminates the nightmare of muscle loss.

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Dental Robot Doesn’t Need Human Assistance

Since developing a surgical robot, engineers across the globe have been pushing the limits of machines in medicine. This Chinese dental robot can perform implant surgery without any human assistance.

The implants were fitted to within a margin of error of 0.2-0.3mm, reaching the required standard for this kind of operation.

The robot addresses the shortage of dental technicians as well as frequent surgical errors. China imports roughly 1 million implants annually, which hardly satisfies the 400 million patients needing new teeth. The Fourth Military Medical University’s hospital takes care of 3D printing dentures.

[Dental staff] programmed the robot to move into the correct position to carry out the operation, and determined the movements, angle and depth needed to fit the new teeth inside a cavity in the patient’s mouth.

The robot adjusts to patients’ movement, which is definitely a plus. It also makes the experience a lot less intimidating, knowing your gums won’t be in for a prickly surprise. It seems surgeons are in for some serious competition.

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“Brainternet” Brings The Human Mind Online

The human brain knows no limits. The fact that we only use 10% of it remains a myth, as antennas and bendable batteries are furthering biomedical engineering. Lately, researchers at Wits University in Johannesburg have made the greatest breakthrough yet with the “Brainternet.” (But it’s not exactly what you might think!)

The project works by taking brainwave EEG signals gathered by an Emotiv EEG device connected to the user’s head. The signals are then transmitted to a low cost Raspberry Pi computer, which live streams the data to an application programming interface and displays the data on an open website where anyone can view the activity.

In essence, you can download information about your brain and pretty much study the thing. So, no, you can’t update your Twitter in your sleep. However, the technology is still potentially valuable in transferring brain data.

“Brainternet can be further improved to classify recordings through a smart phone app that will provide data for a machine-learning algorithm. In [the] future, there could be information transferred in both directions – inputs and outputs to the brain,”

Sorry to disappoint you, millennials, but keep in mind that understanding brain functions could make mind-controlling Facebook possible eventually. For now, stick to a MacBook.

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V.R. Is Helping Doctors Treat Cancerous Tumors

Things are looking up for cancer patients — from gene editing to the humble avocado, various forms of treatment are manifesting all over the world. Now, virtual reality systems are making it easier for doctors to treat cancerous tumors.

Once wearing the Oculus VR headset, the wearer can clearly see how the drug combats certain DNA strands inside the cell of a cancerous growth.

The wearer can then look around 360 degrees inside the tumor to see how the drug attaches itself to DNA strands to help dismantle the cancer.

The Oculus VR can eliminate the need of replica training, which is less practical and more expensive. It also provides users with feedback, allowing surgeons to perform more accurately.

“It is helpful in engaging the brain through interacting with a personalized animation someone is familiar with, so it feels real.”

I suppose this means virtual reality can escape its video game bubble and transition into the education industry. After all, there is always value in new technology.

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Spread The Charitable Holiday Cheer On A Budget

Rolling into the “ber” months has many of us anticipating the upcoming holidays. While December usually means plastic pine trees from Home Depot and the return of Starbucks’ secret menu, it is also a time of giving. Though it’s the simplest and most practical way to help others in need, we aren’t all equipped to donate money. (That is, of course, unless you’re Bill Gates) However, there are a plethora of different ways to spread the charitable holiday cheer on a budget — and it may be more rewarding than you think.

Making a physical donation is easily the most viable option for holiday busybodies. If money isn’t exactly on your side, choose to donate in kind. Considering that the Christmas season rakes in a lot of presents, there are probably household items you can choose to live without. You can pledge clothing to shelters and toys to children’s groups. Books can go to your local library and appliances or electronics can end up in Goodwill. Of course, it is best to ensure that the items in your “give” box are in good condition.

If you can spare a day being proactive, you can opt to give your time. Charities don’t only seek checks and boxes — they need people. Volunteer at a home, whether for the elderly, ill, or four-legged. Chances are, there will be a lot for you to do. A rise in nonprofit groups may leave you with a copious amount of options. If you’re unsure of where to start, figure out where your interests lie and what skills you have to offer. This is where making a list and checking it twice may come in handy. (Scoot over, Santa)

If you are keen on raising funds, plan something income-generating like a garage sale or auction. If you’re without a charity of choice, research a group that could use the money. Remember that you will make the greatest impact by sticking to one organization. A few hundred dollars will go a long way for a single cause as opposed to dividing costs between various groups.

Some people love experiencing the immediate effects of giving back. If you’re handy in the kitchen, consider running a food drive. Get your neighborhood in on the action. Decide what meals are easiest to throw together, and are most cost-efficient. Not only will you satisfy a handful of hungry tummies — you’ll bring the community together.

Needing a change? Or are you simply not so squeamish? Make a medical donation. Blood drives are common during the holidays and a perfectly suitable option for those who have managed to stay in shape. (Perhaps skip the fruit cake?) If you’re not too hot for needles, donate your hair! You’ll be surprised how many people are affected by hair loss due to medical conditions. Moms can also donate breast milk to milk banks.

Giving back can be rewarding, especially if you have the money to do so. But you can choose to be charitable every single day. The time you take to change someone’s life will likely be more meaningful than just a dollar bill.

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Pediatric Cancer Drug Displays 93% Success Rate

Breakthroughs in cancer research such as gene-altering treatments and the discovery of nanomachines have made waves in the past few years, persistently leading humanity through not-so-tiny victory after not-so-tiny victory in a battle between human and disease that has spanned decades. Just this month, a drug specifically targeting a fused gene found in several cancer types resulted in a 93% response rate among children.

“In some cancers, a part of the TRK [tropomyosin receptor kinase] gene has become attached to another gene, which is called a fusion. When this occurs, it leads to the TRK gene being turned on when it’s not supposed to be and that causes the cells to grow uncontrollably. What’s unique about the drug is it is very selective; it only blocks TRK receptors,” said lead author Dr. Ted Laetsch, Assistant Professor of Pediatrics.

Most drugs that are already known and used to cure cancer usually target a particular location or organ in the body. According to the researchers at UT Southwestern’s Simmons Cancer Center, Larotrectinib is the first cancer drug designated for people with TRK fusions, or the fusion of two genes in the cancer cell, regardless of whether their cancer is in the lung, colon, or other areas.

“…none of the patients with TRK fusions had to quit the study because of a drug-induced side effect. Equally important, the response was long-lasting for most patients.”

The TRK fusions tend to occur mostly in certain types of pediatric cancer. This implies that, despite also being 75% effective in adult cancers, Larotrectinib is a bigger breakthrough in pediatric cancer research. This is a hopeful and life-giving discovery for children, or the people most capable of giving us hope in our own lives.

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Millennials are Intensely Changing the Food Industry — Here’s How

 

As the old saying goes, change is the only constant thing in the world. And with a politically engaged and environmentally concerned generation, that should ring very true. Say what you will about millennials — I’m sure opinions vary about the traits that characterize the generation — but they sure bring forth some important changes. Most succinctly, to the food industry.

Millennials are dramatically disrupting the way food is produced, packaged, marketed and served. As a highly vocal group, millennials have given food producers little option but to listen to their demands, resulting in changes to not only food choices, but farming techniques and restaurant services as well.

Though it seems obvious and simple that individual food choices are changing across generations, surely there are bound to be implications on the entire food industry. One of the significant changes on the food landscape is how the word healthy is understood.

While older generations may have contented themselves with vague “low-fat” or “healthy” labels, millennials have higher expectations, especially when it comes to GMOs.

Not only are they exploring healthy Mediterranean diets or looking for meat alternatives, people now have also been advocating for healthier food production techniques. A good nutritional breakdown isn’t enough anymore, this generation wants their food sources organic.

And because of this, healthy has also started to mean local.

[This] has led to a preference for local food brands over national ones, both at the level of production and consumption. Whether buying food at the grocery store or eating out, millennials seek out locally sourced food . . . Some millennials have taken this trend a step further and started to grow their own food in urban and rooftop farms.

True enough, these days, interesting options exist for people who want to try their own hand at producing their own food. Home gardening systems such as OGarden and TerraFarms are now available in the market. So, in addition to being healthy and locally sourced, alternative food sources that millennials encourage are also sustainable.

Another important change in the food industry is the increase popularity of eating out in restaurants.

Technology also plays a major role in making restaurants more popular with younger generations. With apps like the Humane Eating project that combine millennials’ love of technology with sustainable eating, it’s no wonder that more people are exploring new places to eat.

So, to recap, some preferences that millennials have shown the food industry are these: healthy, locally sourced, and sustainably grown. And with how technology and social media work nowadays, it’s no wonder that these choices became demands that the food industry have had to respond to. As a result, more and more huge companies such as Dunkin Donuts’, McDonald’s, and other food giants have been committing to efforts toward sustainability.

It’s only a matter of time before we see how these changes in the food industry will eventually affect other sectors like public health and even the global economy. But it’s amazing to see how individual food choices have led up to this moment. So millennials, don’t be afraid to be bold. Even with your choice of salad for brunch tomorrow.

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Don’t Panic! Dealing with Emergencies through the BeepBeep Nation App

At least once in our lives, I’m sure we have experienced feeling utterly helpless. It may be because we’re alone in an unfamiliar place. It may be because we forgot something vital to our current situation. Other times, it may be because we just downright panic when dealing with emergencies, especially big ones. Panic, unfortunately, often aggravates whatever problem we face. It’s crippling. It might even be dangerous.

But just like how technology has an answer to everything, there might finally be a way to train our minds not to head straight to panic and instead, immediately consider our options and seek help. Especially when there’s an app that’s ready to answer to our needs during any particular crisis  — check out the BeepBeep Nation app.

The BeepBeep Nation App not only offers a platform for people to get the help they need on a daily basis like a ride to work or restaurant recommendations, it can also effectively assist you in dealing with emergencies. That’s what makes it distinct from other service-providing apps. Here’s a list of just some things BeepBeep Nation can help with:

  1. Vehicle breakdown

Not all of us can change a flat tire. Some of us may not even have backup tires ready all the time (though I highly discourage that!). Other times, it may be a serious vehicular damage we’ve never seen before so we have no idea how to fix. Needless to say, you can easily imagine how frustrating it is when your vehicle breaks down and you’re not sure what to do or whom to call for help.

But through BeepBeep Nation, you can simply beep out a help request and users near you will offer to assist with your car problems. Because user responses are always real-time, you can get help anytime. All you need to do are specify some details including these: your vehicle type, your exact location, and your exact problem. It would also help if you can identify if your vehicle needs towing or if you’ve already thought of a solution that you just don’t know how to reach. Let all these facts be known in your beep, and more effective help will arrive more quickly.

Simple, right? Now you can avoid hyperventilating inside a broken down car and instantly be able to deal with it.

2. Medical emergency

Perhaps another more panic-inducing, possibly more hazardous situation is a medical emergency. Whether it’s you, a companion, or someone else that needs medical attention, swift responses are always, always necessary. Every second matters, especially if you’re not certain how serious the case happens to be.

Through BeepBeep Nation, you can quickly receive help from a medic nearby. While waiting for the ambulance to arrive during severe medical problems, for instance, you can beep out a help request for instant first aid response. Of course, there may be times that all you need is a little assistance from a medical officer. Whichever the case, BeepBeep Nation is there to guide you in dealing with emergencies. Check out the illustration above for some of the medical issues that it can help you with.

3. Missing persons or pets

I know, I know. Not panicking when someone you love goes missing is easier said than done. But just keep in mind that blanking out due to extreme emotions isn’t really going to make things better. So after the initial burst, maybe take the time to take care of yourself and calm down first. Because what the situation calls for, as per usual, is action. And BeepBeep Nation provides you a platform to do that.

It will be very helpful to promptly beep out a request on the app when you can’t find a family member or your beloved pet. Specify some necessary details: what they look like, when and where you last saw them, what they were wearing at the time, and other facts that can help BeepBeep Nation users to identify them.

Coming soon to app stores near you, BeepBeep Nation will truly be a life-changing app. Not only can it help requestors attend to their more common everyday needs, helpers to feel good about themselves when helping out, and both of them to socialize and enjoy face-to-face interaction with others, it has a plethora of other important features. And as we’ve seen, one thing it can really help with is dealing with emergencies. Who knows, because we are finally equipped to handle them and avoid panic, BeepBeep Nation might even eventually jumpstart a change in our mindsets.

For now, check out the EMINENT (EMN) token — fuel for the BeepBeep Nation app. Pre-sale is currently live. Don’t hesitate to participate in a world of change. Get started now!

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Extreme Diet Reversed Diabetes in 86% of Patients

For many folks, a “plant-based” or “Mediterranean” diet has been proven by nutritionists as the healthiest. It is linked to many benefits including healthy aging, lower risk of heart disease, improved cognitive function, slower neurodegeneration, and many others. However, for some people who have specific conditions, other regimen — perhaps in some cases, a more extreme diet — may be necessary.

That was the finding of a clinical trial from last year which involved patients with type 2 diabetes. The disease is believed to be reversible even with those who have had it for years, and the trial which made patients engage in an extreme diet attests to this belief; about 86% of those who took part in the study arrived at remission.

“These findings are very exciting,” said diabetes researcher Roy Taylor from Newcastle University. “They could revolutionise the way type 2 diabetes is treated.”

298 adults (20-65 years old) who had been diagnosed with type 2 diabetes within the previous six years participated in the Diabetes Remission Clinical Trial (DiRECT). The participants were randomly assigned to a control group who went under the usual diabetic care or to an experimental group who went under an intensive weight management program. The latter group had to limit their food consumption to 825-853 calories for about three to five months, taking only health shakes and soups.

After this extreme diet, they were slowly reintroduced to more food for a period of two to eight weeks. Alongside it, cognitive behavioral therapy was also provided so that the patients may continue their weight loss and improve their level of physical activity.

Almost 90 percent [or about 86 percent] of those who lost 15 kilograms (33 lbs) or more, successfully reversed their type 2 diabetes. More than half (57 percent) of those dropping 10 to 15 kilograms (22 to 33 lbs) achieved remission also . . .  the control group receiving standard diabetic care management only saw a 4 percent remission rate . . . the average weight loss in the weight management group was 10 kilograms — whereas the control group participants only lost 1 kilogram.

Of course, the remission might not be permanent if patients revert back to unhealthy eating. But the researchers were able to conclude this: dietary intervention can help develop treatment options for type 2 diabetes, a disease that is no longer lifelong or chronic, but ultimately reversible.

The DiRECT program will continue to monitor the groups’ weight loss success and diabetes status. Now here’s to hoping the participants are on the direct path to healthier lifestyles.

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